Pregabalin Powder is a non-gamma-aminobutyric acid (GABA) receptor agonist or antagonist. It is a new type of calcium channel modulator that can block voltage-dependent calcium channels and reduce neurotransmitter freed. Clinically, it is mainly used for neuralgia and postherpetic neuralgia related to diabetic peripheral neuropathy.
Pregabalin Powder can reduce the sensory and motor spinal cord reflexes of the toe tip stimulation in rats, reduce diabetes, peripheral nerve damage or chemotherapy neuropathic animal pain model-related behaviors, and inhibit or reduce spinal irritation caused by Pain-related behavior. It is mainly used clinically for diabetic peripheral neuropathy-related neuralgia, postherpetic neuralgia, and adjuvant treatment of adult partial seizures, generalized anxiety disorder, central neuralgia (including spinal cord injury, stroke, and neuralgia accompanied by multiple sclerosis), and Fibromyalgia.
Product Specification
Item | Specification | Results |
Characteristic | The white or almost white, crystalline powder | White crystalline powder |
Identification A | Positive identification | Complies |
Identification B | Positive identification | Complies |
Melting point | 140 to 145° | 142.1 ~143.1° |
Specific Rotation | -42°to -47.5° | -45.4° |
Limit of Ketones | No deeper than the control solution | Complies |
Sulfates | Not more than 2000 ppm | Complies |
Loss on Drying | Not more than 1.0 % | 0.07% |
Residue on Ignition | Not more than 0.2 % | 0.01% |
Chloride content | 17.0% to 17.7% | 17.50% |
Assay | 97.5% to 102.5 % | 99.90% |
Particle Size | 98% past 40 Mesh | Complies |
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